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KMID : 0351819980390020167
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Kyunpook University Medical Journal
1998 Volume.39 No. 2 p.167 ~ p.172
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Significance of Markers including HBV-DNA in Some HBV-associated Hepatic Diseases
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Kim Jay-Sik
Lee Won-Kil
Suh Jang-Soo
Song Kyung-Eun
Lee Joong-Won
Piao Yuan-Lin
Yang Jung-Sun
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Abstract
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Objective : The interpretation of HBV markets in hepatitis B virus(HBV) associated hepatic diseases is very important in making decision for the diagnosis, progress, effect of treatment and prognosis. Recently applied HBV-DNA mazker seemed to be more informative beside the conventional serologic mazkers as HBsAg etc.
Methods : The ordinary and conventional serologic mazkers of HBsAg, anti-HBs, HbeAg, anti-HBe and anti-HBc(IgM and IgG) were examined by ELISA method. The qualitative and quantitative HBV-DNA were examined by polymetase chain reation(PCR) and Itrminometry respectively. The patient serum specimens were obtained from totally seventeen cases in January 1996.
Results : Negative HBV-DNA cases of the HBV-associated hepatic diseases showed also negative ~. HBsAg and HBeAg mostly. Chronic hepatitis cases revealed high correlation between HBeAg and HBV-DNA marker.
Conclusion : The qualitative and quantitative HBV-DNA appeared to be very useful to evaluate and interpret the states of various HBV-associated hepatic diseases. A trial on interpretation chart for HBV´-associated hepatic disease with HBV-DNA was attempted.
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KEYWORD
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HBV-DNA, PCR, luminometry, HBsAg, anti-HBs, HBeAg anti-HBe, HBV-associated hepatic disease
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